explaining the AMH test

Antimullerian Hormone (AMH) has for some time been considered the most sensitive blood test for measuring a woman's ovarian reserve, but the test hasn't been widely available.  That is changing with the development of a new automated AMH test by Roche.  As well as giving a quick result the literature suggests that the test is more sensitive, more reliable, and more stable than previous tests used.  AMH levels that were previously reported as undetectable may now be measurable.

 

how to read the new AMH levels

  • Results will be lower.  The new test, called Elecsys AMH assay, gives a different set of results to the tests previously used.  Values are 25% lower. So there is potential for confusion in reading and interpreting results.  Laboratories which are now using the new methodology, such as The Doctors Laboratory, will clearly state how to compare the new test results with previous results the patient may have.  Previous AMH levels will be multiplied by 0.75 to achieve a comparable result.

  • Results will be age specific.  The lab reports will include the reference range for the woman's age.

 

how much should we rely on AMH results?

AMH has been shown in studies to be the best measure of ovarian reserve and the most reliable indicator of IVF success, it also gives us an idea of how long a women may have before menopause.  However it is important to note that IVF patients over 40 with extremely low AMH still had a chance of pregnancy.

 

why is AMH important?

http://www.ncbi.nlm.nih.gov/pubmed/25355590 AMH is a reliable predictor of IVF success

http://www.ncbi.nlm.nih.gov/pubmed/25286783 higher AMH levels are associated with higher pregnancy rates with IVF cycles

http://www.ncbi.nlm.nih.gov/pubmed/23640374 AMH levels related to the number of eggs retrieved in women over 40 undergoing their first IVF cycle, however patients with extremely low AMH still had a chance of pregnancy

http://www.ncbi.nlm.nih.gov/pubmed/24821925 AMH is currently the best available measure of ovarian reserve

http://www.ncbi.nlm.nih.gov/pubmed/24077980 AMH and antral follicle count are the most sensitive indicators of ovarian reserve and medication dosage needed during IVF cycles

http://www.ncbi.nlm.nih.gov/pubmed/24435779 AMH is a more reliable predictor of how long a women has before menopause than her mother’s age at onset of menopause

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196774/ about 30% of women undergoing IVF have AMH and antral follicle counts which don’t seem to agree, this study showed that AMH was the more reliable predictor of number of eggs retrieved and pregnancy rates in these women

http://www.ncbi.nlm.nih.gov/pubmed/25319839 AMH may be useful in assessing diminished ovarian reserve in women with autoimmune thyroid disease